Background: Canine visceral hemangiosarcoma (HSA) is a highly aggressive cancer of endothelial origin that\nclosely resembles visceral angiosarcoma in humans, both clinically and histopathologically. Currently there is an\nunmet need for new diagnostics and therapies for both forms of this disease. The goal of this study was to utilize\nChromatin run-on sequencing (ChRO-seq) and immunohistochemistry (IHC) to identify gene and protein expression\nsignatures that may be important drivers of HSA progression.\nResults: ChRO-seq was performed on tissue isolated from 17 HSA samples and 4 normal splenic samples.\nComputational analysis was then used to identify differentially expressed genes and these factors were subjected to\ngene ontology analysis. ChRO-seq analysis revealed over a thousand differentially expressed genes in HSA tissue\ncompared with normal splenic tissue.......................
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